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San Francisco 49ers vs Los Angeles Chargers NFL match analysis, predictions and odds

The Los Angeles Chargers (5-3) travel to the Levi’s Stadium to face the San Francisco 49ers (4-4) on Sunday in a non-conference match-up. A tally of four wins from eight games leaves the San Francisco 49ers with a divisional ranking of second in the NFC West, while the Los Angeles Chargers are second in the AFC West after collecting five victories out of a possible eight. The San Francisco 49ers are the big favorites to snatch the win on the moneyline. Considering how strongly the oddsmakers rate their chances against the Los Angeles Chargers, the home crowd will be anything but impressed if they somehow slip up at the Levi’s Stadium.

Form San Francisco 49ers

The San Francisco 49ers should be confident going into their latest divisional matchup, having won their last three clashes against AFC West teams.

The offense is on an excellent run of form, having put 25.8 points on board in the last five matches, which is more than the 22.0 points that the San Francisco 49ers have managed for the season. Surrendering 18.4 points per game leaves the San Francisco 49ers’ defense around the middle of the pack compared to the rest of the league’s defensive units.

In 2021, the San Francisco 49ers came home in third place in the NFC West standings after going 12-8 across all games. The hosts naturally hope to go even better this season. However, like every other team in the NFL, sealing a spot in the playoff during this regular season is the first and foremost priority for now.

Form Los Angeles Chargers

The Los Angeles Chargers have grabbed an impressive four wins from their five most recent matchups. The away side’s most recent game ended in a 20-17 triumph over the Atlanta Falcons.

The Los Angeles Chargers continue to put up decent numbers in offense, scoring 25.2 points in their last five matches. Considering their season average is 23.0 points, this suggests the offensive unit remains as reliable as ever. On the other side of the ball, the defense has been relatively average in the league recently. The visitors have given up 24.4 points in the previous five outings, which is more or less on par with the 25.8 points they’ve allowed per game over the course of the regular season.

The Los Angeles Chargers began the year backed as a threat for the AFC Championship. While it’s still early days, the vistors remain on course to reach this target. They hold the seventh seed in the AFC Conference and will seek to both maintain and improve their seeding as the regular season winds down.


The San Francisco 49ers claimed a strong 10-15 win, when they were last faced with the Los Angeles Chargers. This encounter took place at the SoFi Stadium. The total has gone under 45.5 points in 13 of the last 19 meetings between the Green Bay Packers and Chicago Bears.

The San Francisco 49ers tallied 21.58 points on average per game from their 19 most recent head-to-head games against the Los Angeles Chargers. The latter managed an average of 19.89 points in comparison.



Take the San Francisco 49ers (1.32) for the outright win on the moneyline. The oddsmakers rate their chances of success on Sunday at 76%, and given their decent run of form at home, it’s easy to see why. The 4-4 hosts have won three of their last four matches at the Levi’s Stadium, leaving their home record for the season at 2-1 SU. Meanwhile, the Los Angeles Chargers are going strong on the road. The visitors have bagged three wins in their past five trips to go 5-4 on the road this season, and are the value bet.


The San Francisco 49ers (1.32) are -7.0 point favorites over the Los Angeles Chargers in the Week 10 betting lines. This leaves the hosts favored to take the win by more than a touchdown on Sunday. A one-score game anyhow seems to be where the smart money lies, as the last five rounds between the San Francisco 49ers and the Los Angeles Chargers produced an average winning margin of 4.4 points.

However, as the San Francisco 49ers have only covered the spread in half of their past 10 home rounds, perhaps they’re a bit 50/50. They are also 5-5 ATS in the last 10 overall.

Based on their regular season record, the Los Angeles Chargers seem a bit of a 50/50 take. The offense ranks as number 18 in the league, averaging 23.0 points per game. However, at the same time, the defense is in position 24 in the defensive rankings after giving up 25.8 points on average. The visitors are 3-2 ATS from their five most recent road trips, as well as 4-6 ATS in their last ten games overall.


The last 19 head-to-head games between and San Francisco 49ers and the Los Angeles Chargers failed to pass the 45 point mark, averaging 41.47 points in total.

Going for the Over (1.32) in Sunday’s matchup at the Levi’s Stadium seems the way to go as the total has gone over in six of the past 19 matchups between the San Francisco 49ers and the Los Angeles Chargers.

The total points score went over in the last two matches for the San Francisco 49ers. Interestedly, the total has gone under in six of the San Francisco 49ers’ past ten matchups against teams from the AFC West.

As for the Los Angeles Chargers, the average total has been 47.7 points in the away team’s past ten matches and 48.2 points in the last five on the road. Looking back over the last five road games, the total went over two times. Overall, the Los Angeles Chargers are 5-4 in the over/under market from their previous ten outings.

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