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San Francisco 49ers vs Arizona Cardinals NFL match analysis, predictions and odds

The Arizona Cardinals (4-12) take to the road as the clear underdogs against the 14-point favorites San Francisco 49ers (12-4) for a Week 18 clash. The match takes place at Levi’s Stadium on Sunday. Going into this NFC West matchup, the Arizona Cardinals sit fourth in the division with four wins from 16 matches, leaving them eight games behind the first-place San Francisco 49ers. With the NFC West locked up, the San Francisco 49ers aim to continue their quest for home-field advantage in the NFC by taking a much-needed victory over the Arizona Cardinals.

Form San Francisco 49ers

The San Francisco 49ers are on a great run of form after making it nine wins in a row by beating the Las Vegas Raiders 34-37 last week, leaving them 9-1 in their last 10 matches.

Playing at Levi’s Stadium brings out the best in the San Francisco 49ers. They have the sixth-best home offensive record, averaging 26.8 points per game with home-field advantage and 25.8 points for all 16 of their regular season games. Defensively, the hosts have the second-best unit of all 32 teams, allowing just 16.5 points on average and 15.0 points on their own ground.

The San Francisco 49ers have clinched a playoff berth after winning their division. The NFC West champions now aim to improve their second seed in the NFC Conference going into the final week of the regular season.

Form Arizona Cardinals

A 20-19 defeat to the Atlanta Falcons last week extended the losing streak of the Arizona Cardinals to six matches. Their record for the last 10 games now stands at 2-8.

The Arizona Cardinals will bring a middle-of-the-park offense for their latest game on the road, having scored 20.4 points per game this season. On the other side of the ball, the defense has been relatively average in the league recently. The visitors have given up 23.0 points in the previous five outings, which is less than the 25.7 points they’ve allowed per game over the course of the regular season.

The Arizona Cardinals will not be making the playoffs this season. While they were expected to struggle, being winless at 4-12 means there is little hope left for them this year. The best they can do now is focus on getting a strong pick in next year’s draft order.


The San Francisco 49ers came away with a 10-38 win in their previous encounter with the Arizona Cardinals at the Estadio Azteca on November 2022. In the last ten NFC West matchups of this series, the Arizona Cardinals came out on top more often than not. The visitors claimed six wins against the San Francisco 49ers, leaving them with an overall record of 6-4.

While the San Francisco 49ers averaged 21.2 points, the Arizona Cardinals performed an average of 21.1 points in their ten most recent head-to-head games.


Arizona Cardinals at San Francisco 49ers odds

Odds for Arizona Cardinals vs San Francisco 49ers is Provided by Bet365. For a full list of odds for the match visit Bet365.com

  • Moneyline (ML): Arizona Cardinals (+600) | San Francisco 49ers (-901)
  • Against the spread (ATS): Arizona Cardinals +14.0 (-110) | San Francisco 49ers -14.0 (-110)
  • Over/Under (O/U): 40.0 (-110) | (-110)

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Take the San Francisco 49ers to win (1.11) outright on the moneyline.

The San Francisco 49ers are an extremely difficult team to beat at home; they have won five straight games and stand 7-1 at Levi’s Stadium and 12-4 for the season. On the other side, Arizona Cardinals have lost six straight games, with two of them coming on the road. That stretch has dropped their record to 4-12.

The San Francisco 49ers have rallied off nine straight wins as they enter Week 18, so it’s no surprise that they are favored over Arizona Cardinals. The Arizona Cardinals have struggled on defense, allowing an average of 25.7 points per game which may justify a spread as high as-14.0

Against the Spread

Betting on the San Francisco 49ers -14.0 (1.91) is our favorite play for this matchup.

The oddsmakers have predicted that the San Francisco 49ers will win this matchup against the Arizona Cardinals by more than a touchdown. The current Week 18 betting lines put the home team as the 14-point favorite over its opponent. The last five contests between the San Francisco 49ers and the Arizona Cardinals have posted an average winning margin of up to 12.2 points.

Taking the San Francisco 49ers on the spread has been worth its weight in gold at home recently, with the hosts covering the spread in their last four matches at the Levi’s Stadium. The hosts are also 7-2 ATS in the past nine games at home and 7-3 ATS overall from their previous ten games.

Over the past 12 games against NFC West opponents, the Arizona Cardinals went 5-7 ATS. Their offense averaged 20.9 points per game during that span, and the defense gave up 23.9 points on average. For covering the spread, the Arizona Cardinals have managed to string together a fine record. They have covered the spread in their last two matchups, going 3-2 ATS in their last five matchups in all.


Total over 40.0 (1.91) is your best bet for this game.

Judging by a points average of 42.3 points from the last ten matchups of this series, the total should land somewhere between 40 and 45 points for the latest encounter between the San Francisco 49ers and Arizona Cardinals.

The total for this game is set at 40.0, a number that is 0.2 points higher than the average of 39.8 points total the two teams have managed in their last five NFL meetings.

The over has proved a profitable pick, paying out in all three of the San Francisco 49ers’ most recent games at Levi’s Stadium. Furthermore, five of the past nine San Francisco 49ers games at the Levi’s Stadium have gone over. They are 7-3 in the over/under betting line from their last ten contests in all.

Meanwhile, the Arizona Cardinals have seen an average of 42.0 points in their past five road games and 48.2 points in their last five contests in all. Over was a winning bet three times in the past five road games for the Arizona Cardinals, who are 7-3 against the total in their last ten home and away games combined.

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