NBA and NFL betting tips and match previews.

San Francisco 49ers vs Los Angeles Chargers NFL match analysis, predictions and odds

In Week 3 of the preseason, the Los Angeles Chargers (1-1) will travel to the San Francisco 49ers (1-1), playing at Levi’s Stadium on Friday. Last season saw the San Francisco 49ers make the playoffs, going 13-4 and finishing top of the NFC West. The Los Angeles Chargers also made the postseason. Their 10-7 record was good enough for second in the AFC West. The San Francisco 49ers overpowered the Los Angeles Chargers 22-16 when they last faced each other. According to the oddsmakers, the home side should have no trouble claiming another win here.

Form San Francisco 49ers

The San Francisco 49ers finally put an end to their losing streak last time out by beating the Denver Broncos 21-20. The victory improved their record from the past eight games to 6-2. They are also 5-0 in the last five at home.

In the preseason, the San Francisco 49ers boast a scoring average of 14.0 points per game. Their offense averaged 25.9 points last season. Defensively, the San Francisco 49ers have given up 27.0 points per preseason game. This is far more than the 17.2 points conceded over the course of the previous campaign.

In the San Francisco 49ers, lies a potential dark horse in the Super Bowl race. This team made it to the NFC Championship game in the previous football season, ending up first in the NFC West standings to boot. They should be capable of at least making it to the playoffs once more this year.

Form Los Angeles Chargers

The Los Angeles Chargers are 1-1 for the preseason and their latest match against the New Orleans Saints finished 17-22.

The Los Angeles Chargers have displayed impressive scoring metrics throughout the preseason. Their offense is averaging 25.5 points per game. Notably, they sustained 23.2 points in the prior season. Defensively, the Los Angeles Chargers conceded an average of 19.5 points during the preseason. They allowed 23.1 points throughout the preceding campaign.

With a formidable roster, the Los Angeles Chargers aim for a deep playoff run. Their sights are set on the AFC Championship Game and the Super Bowl. They are a serious contender, and with a bit of luck, they could go all the way.


The San Francisco 49ers came away with a 22-16 win in their previous encounter with the Los Angeles Chargers at the Levi’s Stadium on November 2022. Victory has gone the San Francisco 49ers’ way six times in their past ten meetings with the Los Angeles Chargers. The hosts are favorites to add another win to this haul, with the oddsmakers laying a home win at 1.29. This implies a 77% winning chance for the San Francisco 49ers.

In their last ten head-to-head games, the San Francisco 49ers managed 23.3 points on average per game, while the Los Angeles Chargers put 19.6 points on board.

Los Angeles Chargers at San Francisco 49ers odds

Odds for Los Angeles Chargers vs San Francisco 49ers is Provided by Bet365. For a full list of odds for the match visit Bet365.com

  • Moneyline (ML): Los Angeles Chargers (3.70) | San Francisco 49ers (1.29)
  • Against the spread (ATS): Los Angeles Chargers +7.5 (1.91) | San Francisco 49ers -7.5 (1.91)
  • Over/Under (O/U): 37.5 (1.91) | (1.91)

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Take the San Francisco 49ers to win (1.29) outright.

Fresh from their 21-20 success against the Denver Broncos, the San Francisco 49ers are the favorites to win. They defeated the Los Angeles Chargers in their last meeting, 22-16. With odds of 1.29, they are backed with an 77% chance of doing so again. Coming off a 17-22 loss to the New Orleans Saints, a swift bounce-back seems uncertain for the Los Angeles Chargers. Their 3.70 odds place them in the underdog position.

Backing the San Francisco 49ers (1.29) to win outright on the moneyline looks too good to pass up. The hosts were strong at Levi’s Stadium last season with an 8-1 record.

Against the Spread

Betting on the Los Angeles Chargers +7.5 (1.91) is our favorite play for this matchup.

The past five contests in this series have been tight, with the average winning margin being just 3.6 points.

The San Francisco 49ers finished with a 13-7 ATS record last season. Their preseason record is 1-1 ATS. In their previous 10 games, the San Francisco 49ers covered seven times, including their last eight at home.

In the preseason, the Los Angeles Chargers have gone 1-1 ATS so far. They went 11-6-1 ATS last season. The Los Angeles Chargers are 3-1 ATS from their four most recent road trips, as well as 4-2-1 ATS in their last seven games overall.


Total over 37.5 (1.91) is your best bet for this game.

Judging by a points average of 42.9 points from the last ten matchups of this series, the total should land somewhere between 40 and 45 points for the latest encounter between the San Francisco 49ers and Los Angeles Chargers.

The average total from the last five encounters between the San Francisco 49ers and Los Angeles Chargers was 42.8 points, 5.3 points more than the 37.5-point total the oddsmakers have set for Friday‚Äôs matchup at the Levi’s Stadium.

The past two San Francisco 49ers games had more points than expected, as the total went over in each of them. Their record last season was 10-10 O/U. The total has gone over in six of the last eight games that the San Francisco 49ers played.

The total has gone over in each of the two preseason games the Los Angeles Chargers have played. Their record last season was 7-10-1 O/U. Over paid out in three of the last four games on the road for the Los Angeles Chargers. In all, they are 4-2-1 in their last seven games overall.

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