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Los Angeles Rams vs San Francisco 49ers NFL match analysis, predictions and odds

Week 2 brings us a highly anticipated clash at SoFi Stadium this Sunday as the Los Angeles Rams take on the San Francisco 49ers. Both teams arrive on the back of impressive opening-week victories, leaving them tied at the top of the NFC West. This game promises exciting football and a chance to establish early-season dominance in the tough NFC West.

Form Los Angeles Rams

In their regular-season opener, the Los Angeles Rams secured a 30-13 victory against the Seattle Seahawks. Yet, it’s important to note that in their last five matches, the Los Angeles Rams have posted a record of 1 win and 4 losses.

The Los Angeles Rams experienced difficulties in getting their offense to run smoothly during the preseason, leading to an average of 11.3 points scored. The previous season had seen them maintain a scoring average of 18.1 points. Defensively, the Los Angeles Rams gave up 36.3 points per preseason game and 22.6 points over the course of the previous campaign.

Despite a challenging season with a 5-12 record and no playoffs, the Los Angeles Rams are ready to come back stronger. They finished third in the NFC West last year but hope to do better this time around. Fans expect a resurgence and a challenge for the top of the NFL.

Form San Francisco 49ers

The San Francisco 49ers kicked off their season in impressive fashion with a dominant 30-7 victory over the Pittsburgh Steelers. However, their recent form has been somewhat inconsistent, as they’ve posted a 2-3 record in their last five games.

The San Francisco 49ers experienced difficulty finding a consistent offensive rhythm during the preseason, averaging 13.3 points per game. They averaged 25.9 points during the prior season. Defensively, the San Francisco 49ers conceded an average of 25.7 points during the preseason. They allowed 17.1 points throughout the preceding campaign.

This season, the San Francisco 49ers are driven by a sense of unfinished business. They are determined to secure their shot at Super Bowl glory this time after coming so close last term. They did everything right, finishing first in the NFC West with a 15-5 record, but lost the one game they couldn’t lose – the NFC Championship Game.


The San Francisco 49ers ran out winners in their previous two matchups with the Los Angeles Rams. They won the most recent meeting 14-31 on October 2022, while the game before that finished with a 24-9 score on October 2022. The implied probability of a third straight win for the San Francisco 49ers (1.28) is 78%. Judging by the way the past ten head-to-head matches played out, the visitors are probably savoring this latest matchup. They have claimed eight wins straight up and only lost two times.

In their past ten head-to-head games, the Los Angeles Rams pulled off 19.9 points on average per game, whereas the San Francisco 49ers managed 26.3 points per match.


San Francisco 49ers at Los Angeles Rams odds

Odds for San Francisco 49ers vs Los Angeles Rams is Provided by Bet365. For a full list of odds for the match visit Bet365.com

  • Moneyline (ML): San Francisco 49ers (1.28) | Los Angeles Rams (3.80)
  • Against the spread (ATS): San Francisco 49ers -7.5 (1.91) | Los Angeles Rams +7.5 (1.91)
  • Over/Under (O/U): 45.0 (1.91) | (1.91)

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Go for the San Francisco 49ers to win (1.28) as your winning pick.

Despite their recent 13-30 win over the Seattle Seahawks, the Los Angeles Rams find themselves as 3.80 underdogs at the SoFi Stadium. Following a 7-30 result against the Pittsburgh Steelers, the San Francisco 49ers enter Week 2 as favorites. They won 14-31 in their previous encounter with the Los Angeles Rams. As a result, they are at 1.28 odds, indicating a 78% implied probability of snatching the win.

It’s crystal clear that all the indicators are aligning for a San Francisco 49ers (1.28) road victory at SoFi Stadium. The odds are firmly in their favor. When you add their two-game winning streak against the Los Angeles Rams to the mix, it becomes hard to envision anything else. The San Francisco 49ers appear poised to extend their dominance in this matchup.

Against the Spread

Go for the Los Angeles Rams +7.5 (1.91) if you’re looking for a safe bet.

In the Week 2 NFL betting lines, the San Francisco 49ers are favored by 7.5 points over the Los Angeles Rams. This leaves the away team as the strong favorite to win. The ten most recent Los Angeles Rams vs San Francisco 49ers matchups in this series have seen an average points margin of 10.2 points.

The Los Angeles Rams are 1-0 ATS for the season. In five of their last seven games, the Los Angeles Rams covered.

The San Francisco 49ers have gone 1-0 ATS on the road. Their overall record for the season is 1-0 ATS. The visitors are 1-2 ATS from their three most recent road trips, as well as 5-3 ATS in their last eight games overall.


Total over 45.0 (1.91) is your best bet for this game.

There was an average of 46.2 points scored in the previous ten clashes between the Los Angeles Rams and the San Francisco 49ers.

In three of the last ten matchups matchups between the Los Angeles Rams and the San Francisco 49ers, the combined points total exceeded the 45.0 Total line. If you choose to bet Under in the Total market for the upcoming Sunday game, you can get odds of 1.91.

The Los Angeles Rams are 0-1 O/U against the total this season. Their record at the SoFi Stadium is 0-0 O/U. The Los Angeles Rams saw an average of 51.0 points in their previous five home games. The score went under in the total line in zero of these contests.

The San Francisco 49ers have gone 0-1 O/U against the total away from home. Their record for the season is 0-1 O/U. The total has gone under in two of the last three San Francisco 49ers road games, averaging 38.7 points. The Under went 3-2 across the previous five matches overall.

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